Re: 30-06 or 243 deer?
My dad who is now 91 has used a 243 since 69 and killed his huge mulies and big elk and large antelope (every year)and a very large bull moose in 85 in his years of hunting in WY.
I never saw him shoot twice.
If you do your your part, that round WILL do exactly what it is supposed to do, every time.
Also go back to what JLR said X ten.
He is right on, IMHO.
For what it is worth,