Most modern made handguns will take a limited number of shots of "+P" ammo. The extra pressure (+P) ammo will quickly loosen and wear out many guns as compared to shooting regular lower pressure ammo. The benefits of of "+P" handgun ammo are questionable, at best, relative to more quickly stopping a violent attacker.
Here is a link to a FBI Paper that everyone who carries a gun should read.
Premium and "+P" ammo can be somewhat likened to fishing lures at Cabela's, Gander Mountain, Bass-Pro, or other large retailers. Often, many lures do a better job of getting less than knowledgeable fisher-persons to buy then than they do relative to catching fish.