Re: Bolt handle tight to lift up on some shots.
I'm with Steve on this one.
34.5 is a long way under the MIN starting point, and that's a recipe for a kaboom.
What manual is that data from and how current is it?
I would back off of the lands at least 0.005" too, maybe even 0.010" to start with.
Once you've got a promising load with your desired powder charge & velocity, then maybe fiddle around with COAL to fine-tune if needed.
Typically, I used WW748 or IMR4064 for .22-250 loads regardless of bullet weight.
Both worked very well in all of my rifles as far as accuracy and velocities.
WW748 was more inconsistent velocity-wise at low temps than 4064 but I could pretty much duplicate the Winchester factory 55gr load accuracy (which my 788 just loved). Since a lot of my shooting is winter coyote hunting my main choice was 4064.
I don't have a .22-250 at the moment...but I'll have another again someday.