Safety affecting loading the gun.
That's a good question. Depends on the gun. Browning-designs (which were all the FNs and all the Colts) the safety also locked the slide. You could put a loaded magazine in the gun, but you could not work the slide to put a round in the chamber. Remington - don't know. Never had one in my hand. Savage and Walther - don't remember, and I'm to lazy to go dig one out of the safe to check.
Luger - safety locks the toggle, so could not load the chamber. Mauser - same thing. Matter of fact, if it's a broomhandle, you have to pull the slide back to load the magazine, so you could not load anything in it with the safety on. Don't know about the Webley autos. Never saw one for real.
Meddle not in the affairs of dragons, for thou art crunchy, and taste good with catsup - George of Lod, Year of Our Lord 297
I always take precautions.
Beware the Evil Bullet Fairies.