Ruger has started and discontinued the 10/22M at least 5 times that I know of due to continuing Fail-to-Extract (FTE) problems.
It's got a lot to do with the bullet...the .22WMR was meant to be a bolt/lever/pump-action round...as semi-autos have had massive problems with it over the years.
So far, only a few companies have ever made reliable semi-auto's in .22WMR...
GRENDEL : Discontinued in 1994 due to that @#$&* Bill Clinton's Assault Weapons Ban.
The Grendel's are probably your best bet...IF you can find one at a decent price...hard as heck to come by these days. Grendel made three .22 WMR semi-autos...the P-30, the P-31, and the R-31 carbine & all had 30-round mags!!!. They kick fuzzy buttock!! Only hiccups...use CCI hi-po rounds and keep the mofo CLEAN. Kind of expensive at auctions...best prices found at pawn shops
AMT Automag II, previously owned, but hated as it didn't cycle very well, so it went bu-bye. Now made by High Standard in Texas. I've not played with the HS version yet.
The Excel Accelerator Pistol & Rifle comes in .17HMR & .22WMR for around $400, and have a Barrel Switch kit for an additional $150. BUT, it only holds 9 rounds...What the heck good is it to make a 9-round semi-auto when the real benefit of small rounds is making hi-capacity EASY??
They are, however, so new that little feedback is available as far as reliability.
Keltec is making the PMR-30, but I have yet to receive mine for testing.
George Kellegren of Keltec designed the PMR-30, Intratec-9, & almost every Grendel pistol.
Remington's 597 in .22WMR has had more blow-ups than Ruger's LCP's.
Marlin made the 922 until 2008, and dropped it due to low sales...but I'm still looking for one
H&K model 300 .22mag semi-auto rifle. Haven't experienced it.
Brno model 611 .22mag semi-auto rifle. Ditto.
Harrington & Richardson Model 700 .22mag semi-auto rifle. Ditto.
So...basically, the best options currently made is the Keltec PMR-30 in Pistol...
and the Excel Accelerator Rifle.
Previous to that, the best I've found were the Grendel pistols & rifle (P-30/P-31/R-31) and the Marlin 922.