The correct answer is, "it depends".
The above target was shot at 25 yards using a near-stock, Tech-Sight equipped Ruger 10/22. The top target (100 yard scaled down target) was fired standing, then kneeling, then prone as I worked my way down the target.
Mag changes get hairy if you don't have something to grab on to! Need banana-style mags.
This is the same drill fired with my squirrel/varmint rifle, a Savage MkII BTVS .22LR. The 'scope was turned down to 4.5x and I don't know that it was that much of a help; I was working the bolt action! I was intimately more familiar with this rifle though as I'd been shooting about 500 rounds per week through it.
The above two were both done at 100 yards with modified CCI Blazer ammo. It's easy to plunk subsonics into one hole, but bulk ammo and supersonic ammo are different propositions. These were weighed and sorted by rim thickness, and modified with D Rock's hollowpointer tool.
Just depends on what you're doing I guess. 110 yards is my self-imposed limit on game with the .22LR. Not because there's not enough power; it's still acting as a heavy .22 Short at that range. It's more because of wind drift and such plus the small vital zones of the critters taken with rimfire cartridges.