I agree with wollyworm. If your load isn't near the high end, go ahead and load 'em up. There shouldn't be much difference, if any, in the primers. However if the load is hot, definitely drop back a bit and work up. Hard to do with only 50 though.
Just FYI, in the future, try to buy components in fairly large lots so you don't have to go thru this exercise very often. "Large" will vary depending on your loading quantities.