Re: 22-250 Reloading
Been loading this cartridge for - oh my! - over three decades. Most rifles twist rates put you into the 52-55 gr. bullet weights to maximize accuracy. I've long used H380, a ball powder, but others in the same rate range ought to work just fine. I use standard CCI primers, but again almost any quality primer with sufficient bresiance will do.
I tend to keep my loads short of max velocity and get 5+ reloadings on them per my logs.
I also do some serious case prep. I clean up the inside of the flash holes, then neck turn to get about .010" clearance in the chamber neck with the selected bullet, and trim brass to the specified dimension. Case length is checked every reload after I just lightly "bump" the shoulder when resizing. I also made several "chamber casts" with cerrosafe so know my rifle's chamber dimensions pretty accurately and can tailor my cases/loads to that one rifle.
Be safe, go slow and have fun !! >MW