I've never ran anything heavier than 55gr through the .22-250. IMR4064 and WW760 are my powders of choice for 40-55gr. I know several shooters that use IMR3031 for those weights too.
I would probably look at a slower burning powder for a heavier bullet...but that's my general thoughts on reloading most all bottleneck cartridges.
IMR4064, WW760, H414, IMR4320...I'd say any of those are worth trying if you've got data for that bullet weight.
And as already mentioned, pay attention to the twist rate on your barrel. The typical 1:14" or 1:12" isn't going to stabilize the heavier (which also means longer) projectiles very well. 1:12" will do most 60gr bullets in the .22-250 or the .220Swift, but I don't know about anything heavier/longer.
I haven't done the Greenhill formula math but the Hornady manual suggest 1:10" for their heavy .224" projectiles.
Here's one site with a Greenhill calculator but there are quite a few more if you do a web search for them.