They are exceptional shooters (I have five 'original' HS pistols, and one of the current-mfg Houston HS pistols). You simply wont find a better .22 pistol. I know, I know, Ruger-Ruger-Ruger, but all that tricking-out we do to the Ruger pistols is just to make them shoot like a High Standard. S&W 41? Nice, but not quite. Woodsman MT? Love 'em, have a couple, but they wont outshoot the HS.
Original High Standard pistols have a devoted collector following - but HS collectors are every bit as persnickety about condition as any Winchester collector, and maybe even more so. Mint HS Supermatic Trophy 106's or 107's, with accessories, and the correct crisp box, will bring every bit of $800. Get some finish wear (and they wear easily), and they drop to shooter-grade at $400 in a BIG HURRY.
High Standard collecting is all about CONDITION, ACCESSORIES and BOXES.
The autonomic nervous system provides for involuntary muscle function - the work of breathing, digestion, and so forth. On some folks, that's a pure waste of ingenuity.