yup, keep a round chambered. If you ever get into a shooting situation, you want the least steps between drawing the gun and bang. Plus when in a shooting situation fine motor skills tend to go out the window so things such as a safety can be a bit of a hassle. This is why many PD's carry pistols w/o safeties such as Sig 229 like i did during my short stint with LPD. Personally I think the more you practice with it, the better you become, so things like operating a safty are more muscle memory than somthing you have to think about. Althogh i agree, racking the slide is precious time that might be critical.