I don't think handgun cartridge's fit anywhere at in the all around cataglory with rifle cartridge's. Get to rifle cartridges and there's a truckload that can make the grade. I doubt any fit the best award but from say a 6.5 on up there are sure a lot that would work. To describe all around I'd say the rifle is everything. For me though that would rule out everything on a case longer than the 308! Probably the closest I've ever come to seeing the perfect one was my old Rem 660 in 308 with a 20" barrel and it had a 3/4x Redfield on it. But I also think the 260Rem, 6.5 CM, 7mm-08 would also work very well, as well as the 308. About all I ever used in that old 660 was 165gr Hornady Spire Point's. In a pinch, that is what I'd think all around suggest's and I'd use that on anything in North America and in the Rem 660 it is a handy rifle easily fitting on the tractor or in the PU. Went bear hunting one spring with a friend in Montana and took that old 660 with 165gr Hornady's. On the way in we saw some grouse and that old gun snipped their heads right off, very accurate rifle, and we had them for dinner. No I suspect the same could have been done with any number of cartridge's but for myself the shorter rifle's with 20" barrel's are extreamely handy and easy to store away. Now it would be quite easy for someone else to claim their 50 BAR would be it. Well whatever trips your trigger! I suspect the 50 BAR could have also taken off the heads of those grouse!