Is there any difference in reloaded cartridges if the case is deprimed before or after cleaning? The difference would be in the primer pocket and flash hole. So I decided to try both ways. Below is a picture of the difference. The cases deprimed before cleaning are the top row - the bottom row are cases that were deprimed after cleaning. There is a very noticeable difference. Not sure if the improved cleanliness makes any difference in the finished cartridge, but I don't like any variation in the reloading process. So I will deprime all cases before cleaning.