...But before jumping into a cartridge different from what the Mauser was originally barreled for, you need to verify the length of cartridge you have chosen will INDEED feed through the Mauser action. There are several different sized Mauser actions...Which do you have?
Dont forget 7mm08 that is what mine is in. You can do 22-250 but a insert would have to be machined into the mag well otherwise they feed funky and jam. 257 roberts is a option too 7mm is its parent case so besides a barrel, there isnt much to do.